TRANSlational and Functional Onco-Genomics
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Partner 12: IPP
Partner name: University of Innsbruck, Medical School, Institute of Pathophysiology
Short name: IPP
Country: Austria
Role: CR (contractor)
Defects in cell cycle and apoptosis regulation are causally implicated in lymphoid malignancies, and glucocorticoids (GC) as well as non-specific chemotherapeutic drugs that arrest cell cycle progression and/or induce cell death are used therapeutically. We propose a functional genomics approach towards identifying critical target genes involved in these processes. The respective techniques (whole genome expression profiling, large scale RNAi-based screening with newly developed vectors) will further be made available to the entire consortium. IPP will also produce spotted oligonucleotide microarrays, for comparative analysis and for screenings across the Consortium members.
Relevant Expertise
Stephan Geley DR
Tet-regulated siRNA vectors
Reinhard Kofler PROF
Molecular haematology
  • Ausserlechner, Geley, Kofler. 2001. The cell cycle inhibitor p16/INK4A sensitizes lymphoblastic leukemia cells to apoptosis by physiologic glucocorticoid levels. J.Biol.Chem. 276:10984-10989.
  • Geley S, Tim Hunt. 2001. APC/C-dependent proteolysis of human cyclin A starts at the beginning of mitosis and is not subject to the spindle assembly checkpoint. J Cell Biol. 153: 137.
  • Tonko, M., R. Kofler. 2001. Gene expression profiles of proliferating versus G1/G0 arrested human leukemia cells suggest a mechanism for glucocorticoid-induced apoptosis. FASEB J. 15:693-699.
  • Obexer, Kofler, Helmberg. 2001. Expression profiling of glucocorticoid - treated T-ALL cell lines: rapid repression of multiple genes involved in RNA-, protein- and nucleotide synthesis. Oncogene 20:4324.
  • Löffler, M., S. Geley, A. Helmberg, and R. Kofler. 1999. c-myc does not prevent glucocorticoid-induced apoptosis of human leukemic lymphoblasts. Oncogene 18:4626-4631.
OECI week

OECI Week (WG workshops; Scientific Conference and General Assembly) – Budapest, 16 to 18 June 2010.
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