TRANSFOG
TRANSlational and Functional Onco-Genomics
Sixth_Framework
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Partner 2: IRCC
Partner name: Fondazione Piemontese per la Ricerca sul Cancro - ONLUS
Short name: IRCC
Country: Italy
Role: CR (contractor) - Scientific coordinator
The Fondazione Piemontese per la Ricerca sul Cancro - ONLUS (Piedmontese Foundation for Cancer Research) is a private-non-profit organization aimed at promoting and conducting, directly or indirectly, research in both experimental oncology and clinical oncology, as well as the development of new diagnostic and therapeutic tools useful for cure of the disease. Through its partner IRCCSpA, the FPRC supports and runs a comprehensive cancer centre named "Institute for Cancer Research and Treatment" (IRCC) located in Italy at Candiolo, Turin. Cancer research activities at the Institute are carried out in affiliation with the University of Turin Medical School. Prof. Paolo M. Comoglio is the Scientific Director of the Foundation and of the Institute. Over the last few years, studies at the IRCC on action mechanisms of the Met and Ron tyrosine kinase receptors have given a definition to the concept "invasive growth," a genetic program of cell migration and organization that is essential during organogenesis and angiogenesis, and is pathologically activated when a tumour acquires an invasive-metastatic phenotype. IRCC researchers have also discovered and characterized plexins, a family of related genes, and is studying their role in the genesis of metastasis. Finally, functional genomics approaches including DNA microarray and gene trapping allowed initial elucidation of the invasive growth genetic program. IRCC will be the Scientific Coordinator of TRANSFOG and of its workpackage 4 (systematic gene functional analysis). To achieve optimal efficacy it the coordination effort, the PI's outstanding expertise in the field of molecular oncology will be further supported by the specific functional oncogenomics competences of Dr. Enzo Medico.
PERSONNEL :
Personnel
Title
Relevant Expertise
Sex
Paolo M. Comoglio Prof Scatter Factor-driven invasive growth M
Enzo Medico Dr Functional genomics M
Federico Bussolino Prof In vitro and in vivo angiogenesis M
Silvia Giordano Prof Signal transduction of the Met-Plexin family of receptors F
REFERENCES:
  • Giordano et al., 2002. The semaphorin 4D receptor controls invasive growth by coupling with Met. Nat Cell Biol. 4:720-4.
  • Trusolino L, Comoglio PM. Scatter-factor and semaphorin receptors: cell signalling for invasive growth. Nat Rev Cancer. 2002 Apr;2(4):289-300. Review.
  • Trusolino L, Bertotti A, Comoglio PM. A signaling adapter function for alpha6beta4 integrin in the control of HGF-dependent invasive growth. Cell. 2001 Nov 30;107(5):643-54.
  • Medico et al., 2001. A gene trap vector system for identifying transcriptionally responsive genes. Nat Biotechnol. 19:579-82.
    Serini et al., Modeling the early stage of vascular network assembly, EMBO J 2003 (in press)
UPCOMING EVENT
OECI week

OECI Week (WG workshops; Scientific Conference and General Assembly) – Budapest, 16 to 18 June 2010.
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