TRANSFOG
TRANSlational and Functional Onco-Genomics
Sixth_Framework
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Major milestones over the full project duration
MONTH 6
A bioinformatic system for data sharing and gene annotation is operative The first datasets of cancer-oriented screenings from the Consortium are generated (100 datasets) and shared; preliminary version of molecular signatures for metastasis Assembly of the initial ranked list of genes of poorly known function potentially involved in cancer progression and metastasis, to instruct the FL-cDNA and siRNA clone collection projects
MONTH 12
A first lot of the clone collections is assembled (cDNA and siRNA vectors): (i) batch of ~40 cancer-related FL-cDNAs, Gateway-cloned and verified; (ii) batch of ~900 siRNA clones targeting 300 candidate cancer genes Functional and interaction screenings are set-up for high-throughput analysis Assays for diagnostic validation are set-up and tumour samples dedicated to this task are selected
MONTH 24
Clone collections are mostly completed First batch of results from the in vitro functional and interaction assays and from the validation activities
MONTH 36
Functional and interaction assays mostly completed in vitro, first preliminary results on in vivo analysis Preliminary diagnostic validation completed, diagnostic gene sets can be selected for exploitation and dissemination as diagnostic tools
MONTH 48
New molecular targets for anticancer therapy are defined through the complete functional characterization pipeline, partners are identified for exploitation and translation of the results Diagnostic gene sets are widely validated and disseminated across European cancer centers
UPCOMING EVENT
OECI week

OECI Week (WG workshops; Scientific Conference and General Assembly) – Budapest, 16 to 18 June 2010.
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Develped and maintained by MEDINFO - DIST Updated : 27 April 2010
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