TRANSlational and Functional Onco-Genomics
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The Work Programme for the First 18 Month
The implementation plan for the first 18 months reflects the general structure of the Project, with 7 research activities detailed in 7 research Work Packages (WPs):
  • WP1: Cancer-Oriented Genomic Screenings
  • WP2: Enabling Systematic Gene Gain-of-Function
  • WP3: Enabling Systematic Gene Downregulation
  • WP4: Definition of New Molecular Targets for Innovative Cancer Therapy
  • WP5: Proteomic Dissection of Cancer Signalling Pathways
  • WP6: Clinical Validation of Cancer Molecular Signatures
  • WP7: Generation of a Shared Platform for Data Handling and Gene Functional Annotation
There are precise dependencies between the WPs. The outcome of WP1, the list of candidate cancer genes resulting from the screenings, instructs WP2 and WP3 for the production of tools for specific gene gain- and loss-of-function, respectively. These tools are essential for WP4 and WP5, that carry out systematic analysis of gene function and signal transduction. WP1 also instructs WP6 with the definition of molecular signatures of potential clinical value to be validated. Last but not least, WP7 enables data standardization, sharing and mining, which is an essential prerequisite for all other WP's. Notwithstanding these dependencies, the WP's time frame is envisioned as a parallel one, with WP's relying on the outcomes of other WP's starting at their same time. This paradox can be simply explained with the fact that "downstream" WP's have a setup phase, in which protocols and assays have to be optimised and standardised, and the early delivery of a reference set of material from the upstream WP's is sufficient to have them start, together with access to published data and commercially available products.
Three more WPs will be dedicated to supporting the Research WPs, these are Work Packages 8, 9 and 10:
  • WP 8: Assessment, Translation, Dissemination and Exploitation
  • WP 9: Training
  • WP 10: Project Management

Altogether, the proposed workpackages will allow reaching a first series of key objectives of the TRANSFOG project, in particular:

  • Identification of a first set of novel cancer-related genes of high clinical-diagnostic potential;
  • Set-up of technologies for systematic cancer gene functional analysis, for identification of new molecular targets and for systematic exploration of oncogenic/antioncogenic signalling pathways and epigenetic regulatory mechanisms;
  • Development of tools for diagnostic validation of cancer molecular signatures with high predictive and/or prognostic value in cancers of high population impact;
  • Establishment of a shared bioinformatic platform for functional oncogenomics data handling and standardization.
OECI week

OECI Week (WG workshops; Scientific Conference and General Assembly) – Budapest, 16 to 18 June 2010.
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Develped and maintained by MEDINFO - DIST Updated : 27 April 2010
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