TRANSFOG
TRANSlational and Functional Onco-Genomics
Sixth_Framework
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Partner 6: UMCU
Partner name: University Medical Center Utrecht
Short name: UMCU
Country: Netherlands
Role: CR (contractor)

The focus of this unit is signal transduction and transcriptional control in cancer, focussed on three pathways, which are very frequently mutated in human cancer: the Ras signalling pathway (Bos), the APC-b-catenin-Tcf pathway (Clevers) and the PI-3-Kinase-PTEN-PKB-FoxO pathway (Burgering). Bos has in the past established the importance of Ras mutations in human cancers and since then studied the function of the Ras signalling pathway. Clevers co-discovered the b-catenin-Tcf interaction and made many contributions to our understanding of the role of this pathway in colorectal cancer. Burgering co-discovered the PI-3 kinase-PKB/Akt connection, and the connection of PKB with the control of the cell cycle through FoxO transcription factors. All three PI's are leading scientists in their field. UMCU will coordinate workpackage 5, aimed at proteomic dissection of oncogenic/ antioncogenic signalling pathways.

PERSONNEL
Name
Title
Sex
Relevant Expertise
Johannes Lukas Bos PROF
M
Ras signalling
Hans C Clevers PROF
M
Wnt signalling
Boudewijn Burgering PROF
M
Akt/PKB signalling
Marta Roccio MS
F
Proteomics
Mike Zhang MR
M
Signal transduction
REFERENCES:
  • Medema et al., 2000. AFX-like Forkhead transcription factors mediate cell-cycle regulation by Ras and PKB through p27kip1. Nature. 404, 782-787.
  • Kops et al., 2002. Forkhead transcription factor FOXO3a protects quiescent cells from oxidative stress. Nature 419, 316-321.
  • de Rooij et al., 1998. Epac is a Rap1 guanine-nucleotide-exchange factor directly activated by cyclic AMP. Nature 396, 474-477.
  • Batlle et al., 2002. Beta-catenin and TCF mediate cell positioning in the intestinal epithelium by controlling the expression of EphB/ephrinB. Cell. 2002, 111, 251-263.
  • van de Wetering et al., 2002. The beta-catenin/TCF-4 complex imposes a crypt progenitor phenotype on colorectal cancer cells. Cell. 111, 241-250.
UPCOMING EVENT
OECI week

OECI Week (WG workshops; Scientific Conference and General Assembly) – Budapest, 16 to 18 June 2010.
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