TRANSFOG
TRANSlational and Functional Onco-Genomics
Sixth_Framework
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Partner 18: WIS
Partner name: The Weizmann Institute of Science
Short name: WIS
Country: Israel
Role: CR (contractor)

Next-generation therapy of carcinomas driven by neuregulins and oncogenic tyrosine kinases will be addressed by this group through:

(i) Genome-wide screening for mechanisms that negatively regulate signal transduction. The feasibility of harnessing the identified mechanisms for therapy will be examined.

(ii) Elucidation of modulators of ErbB-2/HER2 stability using systematic loss of function analysis and automated fluorescent readouts.

(iii) Establishment of diagnostic tools for patient-tailored therapy based on genomic sequences of neuregulins and expression profiles.

PERSONNEL
Name
Title
Sex
Relevant Expertise
Yosef Yarden
PROF
M
Signal transduction, oncogenesis, protein-protein interactions
Mina Marmor
DR
F
Immunology, yeast two hybrid screens, tyrosine kinases.
Gal Gur-Shachar
DR
F
Negative regulators of ErbB, ubiquitylation assays, phosphorylation assays and siRNA.
Gabriele Kerber
DR
F
Growth factor cloning and expression, stable transfections, functional readouts in vitro
Sara Lavi
MS
F
Plasmid and viral vectors (technical)
REFERENCES:
  • Citri, A., Alroy, I., Lavi, S., Rubin, C., Xu, W., Grammatikakis, N., Patterson, C., Neckers, L., Fry, D. W., and Yarden, Y. (2002). Drug-induced ubiquitylation and degradation of ErbB receptor tyrosine kinases: implications for cancer therapy, Embo J 21, 2407-17.
  • Katz, M., Shtiegman, K., Tal-Or, P., Yakir, L., Mosesson, Y., Harari, D., Machluf, Y., Asao, H., Jovin, T., Sugamura, K., and Yarden, Y. (2002). Ligand-Independent Degradation of Epidermal Growth Factor Receptor Involves Receptor Ubiquitylation and Hgs, an Adaptor Whose Ubiquitin-Interacting Motif Targets Ubiquitylation by Nedd4, Traffic 3, 740-751.
  • Oved, S., and Yarden, Y. (2002). Signal transduction: molecular ticket to enter cells, Nature 416, 133-6.
  • Waterman, H., and Yarden, Y. (2001). Molecular mechanisms underlying endocytosis and sorting of ErbB receptor tyrosine kinases, FEBS Lett 490, 142-52.
  • Yarden, Y., and Sliwkowski, M. X. (2001). Untangling the ErbB signalling network, Nat Rev Mol Cell Biol 2, 127-37
UPCOMING EVENT
OECI week

OECI Week (WG workshops; Scientific Conference and General Assembly) – Budapest, 16 to 18 June 2010.
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Develped and maintained by MEDINFO - DIST Updated : 27 April 2010
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